Findings from confirmatory randomized trials are generally considered to represent a higher level of evidence than findings from observational studies. Manuscripts presenting randomized trials usually get more favourable evaluations and have lower chances of being rejected. Many authors of observational studies have recognized this phenomenon and try to use the knowledge in order to improve… Continue reading Observational or experimental?
It is quite easy to get a manuscript accepted in a scientific journal if only a few basic requirements are met, i.e. a reasonably interesting research question, a sound study design, and generally acceptable results. Unfortunately, the chance of succeeding with this in a randomised trial is not great. Randomised trials are expensive, time-consuming, and… Continue reading HARKing